Product Details
| Product Name:
JYL 1421 |
CAS No.:
401907-26-4 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | JYL 1421 |
| Description | JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM). |
| In vitro | JYL 1421(5 min) inhibits the capsaicin (330 nM)-evoked Ca2+ accumulation in a concentration-dependent manner. The inhibitory effect of the lowest concentration (5 nM) of JYL 1421 reaches the level of significance and 1 μM almost abolishes the response, only 3.1±0.65% of the first capsaicin-induced Ca2+ influx could be observed[1]. |
| In vivo | Intravenous capsaicin injection at 1 and 2 μg/kg causes a temporary blood pressure drop of 47.4±4.7 and 59.6±4.2 mmHg (n=6), respectively. JYL 1421 at 0.4 and 1.6 mg/kg does not induce hypotension but inhibits the capsaicin-induced blood pressure drop in a dose-dependent manner, necessitating higher capsaicin doses to trigger reflex hypotension post-administration. Capsazepine up to 2 mg/kg does not significantly inhibit capsaicin-evoked hypotension. Capsaicin solution (50 μL, 10 μg/mL) instilled into the left eye of rats causes 12.9±1.3 wiping movements within 3 minutes. Pretreatment with JYL 1421 (0.4 or 1 mg/kg i.p.) does not significantly affect wiping behavior, but doses of 2-5 mg/kg reduce the movements dose-dependently with an ID50 value of 4.6 mg/kg. The mean arterial pressure of untreated rats is 109.9±4.2 mmHg (n=6)[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | JYL-1421 | inhibit | Inhibitor | SC0030 | JYL1421 | TRP Channel | Transient receptor potential channels | JYL 1421 | SC-0030 |
| Inhibitors Related | (+)-Camphor | AP 18 | Methyl syringate | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Methyl salicylate | SKF-96365 hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1820.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States