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Postion:Product Catalog >JTP 0819958 - HOIPIN-1
JTP 0819958 - HOIPIN-1
  • JTP 0819958 - HOIPIN-1

JTP 0819958 - HOIPIN-1 NEW

Price $33 $45 $63
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: JTP 0819958 - HOIPIN-1 Purity: 95.08%
Supply Ability: 10g Release date: 2024/11/14

Product Introduction

Bioactivity

名稱JTP 0819958 - HOIPIN-1
描述JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
體外活性JTP-0819958 inhibited the linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex, and the HOIP/SHARPIN complex equally, with IC50 values of 4.4, 3.5, and 3.7μM. The inhibitory effects of JTP-0819958 on LUBAC-mediated linear ubiquitin generation and inflammatory cytokine-induced NF-κB activation were confirmed in cellular levels.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 3.04 mg/mL (10 mM), Sonication is recommended.
關(guān)鍵字JTP 0819958 HOIPIN1 | JTP 0819958 HOIPIN 1 | JTP 0819958 - HOIPIN-1
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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