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Postion:Product Catalog >JNJ-65355394
JNJ-65355394
  • JNJ-65355394

JNJ-65355394 NEW

Price $117 $279 $397
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-16

Product Details

Product Name: JNJ-65355394 CAS No.: 2230598-99-7
Purity: 99.55% Supply Ability: 10g
Release date: 2024/11/16

Product Introduction

Bioactivity

名稱JNJ-65355394
描述JNJ-65355394 is an effective O-GlcNAc hydrolase (OGA) inhibitor and an OGA chemical probe.
體外活性JNJ-63533054 induced luciferase activity against zebrafish GPR139 in a concentration-dependent manner. For zebrafish GPR139, the maximal induction of 3.3-fold of vehicle control was achieved at a concentration of 128nM. From the dose-response curve, the half effective maximal concentration (EC50) values of JNJ-63533054 to zebrafish GPR139 was 3.91nM.[1]
體內(nèi)活性JNJ-63533054 specifically activates human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. JNJ-63533054 also activates the rat and mouse GPR139 receptor with similar potency (rat EC50 = 63 ± 24 nM, mouse EC50 = 28 ± 7 nM). [2] JNJ-63533054 crosses the rat blood-brain barrier after oral administration and achieves exposure in the micromolar range. JNJ-63533054 administration decreases spontaneous locomotor activity in rats.[2]
存儲(chǔ)條件Shipping with blue ice.
溶解度DMSO : 30 mg/mL (83.68 mM)
關(guān)鍵字JNJ65355394 | JNJ 65355394 | JNJ-65355394
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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