JNJ-42226314 NEW
Price | $48 | $113 | $183 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-12 |
Product Details
Product Name: JNJ-42226314 | CAS No.: 1252765-13-1 |
Purity: 99.62% | Supply Ability: 10g |
Release date: 2024/11/12 |
Product Introduction
Bioactivity
名稱 | JNJ-42226314 |
描述 | JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain. |
體外活性 | After treatment with PF-3845 ( 1 or 10 μM ), JZL-184 ( 1 or 10 μM ), JNJ-42226314 ( 1 or 10 μM ) or carrier ( DMSO ), JNJ-42226314 was selectively analyzed by competitive ABPP. The results showed that JNJ-42226314 had high selectivity for MAGL [1]. |
體內(nèi)活性 | In male C57Bl/6 mice weighing 20-30g and male Sprague-Dawley rats weighing 300-400g, treatment with JNJ-42226314 (3 mg/kg and 30 mg/kg; i.p.; 120 min) dose-dependently elevated hippocampal 2-AG levels in vivo[1]. |
存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 100 mg/mL (204.26 mM), Sonication is recommended. |
關(guān)鍵字 | JNJ 42226314 | JNJ42226314 | JNJ-42226314 |
相關(guān)產(chǎn)品 | Atglistatin | WWL70 | KML29 | Y-320 | ABX-1431 | JJKK 048 | Endothelial lipase inhibitor-1 | XEN445 | NG-497 | Beta-Sitosterol |
相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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