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Postion:Product Catalog >JNJ-42226314
JNJ-42226314
  • JNJ-42226314

JNJ-42226314 NEW

Price $48 $113 $183
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-08

Product Details

Product Name: JNJ-42226314 CAS No.: 1252765-13-1
Purity: 99.62% Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱JNJ-42226314
描述JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic pain and inflammatory pain.
體外活性After treatment with PF-3845 ( 1 or 10 μM ), JZL-184 ( 1 or 10 μM ), JNJ-42226314 ( 1 or 10 μM ) or carrier ( DMSO ), JNJ-42226314 was selectively analyzed by competitive ABPP. The results showed that JNJ-42226314 had high selectivity for MAGL [1].
體內(nèi)活性In male C57Bl/6 mice weighing 20-30g and male Sprague-Dawley rats weighing 300-400g, treatment with JNJ-42226314 (3 mg/kg and 30 mg/kg; i.p.; 120 min) dose-dependently elevated hippocampal 2-AG levels in vivo[1].
存儲條件store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 100 mg/mL (204.26 mM), Sonication is recommended.
關(guān)鍵字JNJ 42226314 | JNJ42226314 | JNJ-42226314
相關(guān)產(chǎn)品Atglistatin | WWL70 | KML29 | Y-320 | ABX-1431 | JJKK 048 | Endothelial lipase inhibitor-1 | XEN445 | NG-497 | Beta-Sitosterol
相關(guān)庫疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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