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Postion:Product Catalog >JKE-1674
JKE-1674
  • JKE-1674

JKE-1674 NEW

Price $48 $113 $183
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-05

Product Details

Product Name: JKE-1674 CAS No.: 2421119-60-8
Purity: 98.72% Supply Ability: 10g
Release date: 2024/11/05

Product Introduction

Bioactivity

名稱JKE-1674
描述JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
體外活性JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1].
體內(nèi)活性Mice can be orally dosed with JKE-1674 and the compound can be detected in the serum for up to 24 hours.[1]
存儲條件keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 13 mg/mL (28.81 mM)
關(guān)鍵字ML210 | glutathione | Ferroptosis | peroxidase | inhibit | JKE1674 | JKE-1674 | JKE 1674 | Glutathione Peroxidase | rescued | Inhibitor
相關(guān)產(chǎn)品GPX4-IN-6 | 3-Deoxyglucosone | ML-210 | RSL3 | ML162 | BCP-T.A | GPX4-IN-5 | PKUMDL-LC-101-D04 | N6F11 | Misonidazole
相關(guān)庫經(jīng)典已知活性庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.
2024-10-28
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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