Product Details
Product Name:
JKE-1674 |
CAS No.:
2421119-60-8 |
Purity:
98.72% |
Supply Ability:
10g |
Release date:
2024/11/05 |
Product Introduction
Bioactivity
名稱 | JKE-1674 |
描述 | JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors. |
體外活性 | JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1]. |
體內(nèi)活性 | Mice can be orally dosed with JKE-1674 and the compound can be detected in the serum for up to 24 hours.[1] |
存儲條件 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 13 mg/mL (28.81 mM)
|
關(guān)鍵字 | ML210 | glutathione | Ferroptosis | peroxidase | inhibit | JKE1674 | JKE-1674 | JKE 1674 | Glutathione Peroxidase | rescued | Inhibitor |
相關(guān)產(chǎn)品 | GPX4-IN-6 | 3-Deoxyglucosone | ML-210 | RSL3 | ML162 | BCP-T.A | GPX4-IN-5 | PKUMDL-LC-101-D04 | N6F11 | Misonidazole |
相關(guān)庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 口服活性化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$1520.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |