JH-II-127 NEW
Price | $64 | $103 | $178 |
Package | 5mg | 10mg | 25mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-04 |
Product Details
Product Name: JH-II-127 | CAS No.: 1700693-08-8 |
Purity: ≥98% | Supply Ability: 10g |
Release date: 2024/11/04 |
Product Introduction
Bioactivity
名稱 | JH-II-127 |
描述 | JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively. |
體內(nèi)活性 | JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro.?It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 30 mg/mL (71.97 mM) |
關(guān)鍵字 | HEK293 | JHII127 | 3T3 cells | Inhibitor | LRRK2-G2019S | Ser935 | Leucine-rich repeat kinase 2 | LRRK2 | JH-II127 | parkinson’s disease | JH-II-127 | JH-II 127 | inhibit | JH II 127 | LRRK2-A2016T |
相關(guān)產(chǎn)品 | PFE-360 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | CZC-54252 hydrochloride | GNE-7915 | EB-42486 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 | CCG-1423 |
相關(guān)庫 | 高選擇性抑制劑庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 激酶抑制劑庫 | 自噬庫 | 抗帕金森病化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$2140.00/25mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
$1440.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
$0.00/10mg |
VIP1Y
|
ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-04-10 | |
$1.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2019-12-26 |
- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY