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Postion:Product Catalog >JH-II-127
JH-II-127
  • JH-II-127

JH-II-127 NEW

Price $64 $103 $178
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-04

Product Details

Product Name: JH-II-127 CAS No.: 1700693-08-8
Purity: ≥98% Supply Ability: 10g
Release date: 2024/11/04

Product Introduction

Bioactivity

名稱JH-II-127
描述JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively.
體內(nèi)活性JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro.?It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 30 mg/mL (71.97 mM)
關(guān)鍵字HEK293 | JHII127 | 3T3 cells | Inhibitor | LRRK2-G2019S | Ser935 | Leucine-rich repeat kinase 2 | LRRK2 | JH-II127 | parkinson’s disease | JH-II-127 | JH-II 127 | inhibit | JH II 127 | LRRK2-A2016T
相關(guān)產(chǎn)品PFE-360 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | CZC-54252 hydrochloride | GNE-7915 | EB-42486 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 | CCG-1423
相關(guān)庫高選擇性抑制劑庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 激酶抑制劑庫 | 自噬庫 | 抗帕金森病化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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