Isonicotinamide NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-30 |
Product Details
| Product Name: Isonicotinamide | CAS No.: 1453-82-3 |
| EC-No.: 215-926-2 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/30 |
| CAS: | 1453-82-3 |
| MF: | C6H6N2O |
| MW: | 122.12 |
| EINECS: | 215-926-2 |
| Product Categories: | Apoptosis, Aromatics, Heteocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Pyridine |
| Mol File: | 1453-82-3.mol |
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| Isonicotinamide Chemical Properties |
| Melting point | 155-157 °C(lit.) |
| Boiling point | 227.52°C (rough estimate) |
| density | 1.2236 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | pK1: 3.61(+1) (20°C) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 191.7 g/L (37 oC) |
| BRN | 2173 |
| LogP | -0.28 |
| CAS DataBase Reference | 1453-82-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Pyridinecarboxamide(1453-82-3) |
| EPA Substance Registry System | Isonicotinamide (1453-82-3) |
| Isonicotinamide Usage And Synthesis |
| Chemical Properties | white crystalline powder |
| Uses | Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60. |
| Application | Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize: 4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents. Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies. Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin. Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals. |
| Preparation | synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%. |
| Definition | ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid. |
| Purification Methods | Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.] |
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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