Isoliquiritigenin NEW
| Price | $50 |
| Package | 20mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Isoliquiritigenin | CAS No.: 961-29-5 |
| Purity: 99.44% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Isoliquiritigenin |
| Description | Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity. |
| In vitro | METHODS: Normal human hepatocyte cell line LO2 and HCC cell line Hep3B were treated with Isoliquiritigenin (30-60 μM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: Isoliquiritigenin showed significant cytotoxicity against Hep3B cells with an IC50 of 42.84±2.01 μM at 48 h. This effect was concentration and time dependent. However, at the same Isoliquiritigenin stimulation intensity, the survival of LO2 cells was significantly less affected with an IC50 >60 μM.[1] METHODS: Human colorectal cancer cells HCT-116 were treated with Isoliquiritigenin (20 μM) for 24 h. Apoptosis was detected by Flow cytometry. RESULTS: Treatment of HCT-116 cells with Isoliquiritigenin resulted in a significant increase in apoptosis (17.26%) in the treated group compared to the NC group (7.37%). [2] |
| In vivo | METHODS: To assay anti-tumor activity in vivo, Isoliquiritigenin (50 mg/kg) was injected intraperitoneally into BALB/c-nu/nu mice bearing Hep3B xenografts once daily for three weeks. RESULTS: Isoliquiritigenin-treated mice had reduced tumor burden in terms of mean tumor size or xenograft weight. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.1 mg/mL (19.9 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 60 mg/mL (234.15 mM) Ethanol : 22 mg/mL (85.9 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | SJ 000286237 | Inhibitor | SJ-000286237 | Aldose Reductase | Autophagy | Apoptosis | inhibit | Isoliquiritigenin | SJ000286237 | GU-17 | GU 17 | Influenza Virus |
| Related Compound Libraries | Flavonoid Natural Product Library | Flavor Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Viral Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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