Isoliensinine NEW
| Price | $30 | $63 | $90 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Isoliensinine | CAS No.: 6817-41-0 |
| Purity: 99.04% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Isoliensinine |
| Description | Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities. |
| In vitro | METHODS: Human breast cancer cells MDA-MB-231 were treated with Isoliensinine (1-40 μM) for 24-72 h. Cell viability was measured by CCK-8 Assay. RESULTS: Isoliensinine exhibited anticancer properties in MDA-MB-231 cells, with estimated IC50 values of 108.1 μM, 22.78 μM, and 18.34 μM at 24 h, 48 h, and 72 h, respectively. [1] METHODS: Cervical cancer cells C33A, Caski, HeLa and SiHa were treated with Isoliensinine (5-40 μM) for 24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Isoliensinine significantly reduced CDK2 and cyclin E at the protein level in a dose-dependent manner in the four cervical cancer cells. [2] |
| In vivo | METHODS: To investigate the effects on pulmonary fibrosis in mice, Isoliensinine (10-40 mg/kg) was orally administered three times daily for 14 days to Kungming mice with bleomycin (BLM)-induced pulmonary fibrosis. RESULTS: Isoliensinine exerted a significant inhibitory effect on BLM-induced pulmonary fibrosis, which may be due to its antioxidant and/or anti-inflammatory activity as well as inhibition of BLM-induced overexpression of TNF-α and TGF-β1. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc. : Soluble DMSO : 55 mg/mL (90.05 mM) |
| Keywords | Apoptosis | Isoliensinine | Inhibitor | inhibit |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Myricetin | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | L-Cystine | Salicylic acid | Oleic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-Viral Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-virus Traditional Chinese Medicine Monomer Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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