iRGD peptide NEW
| Price | $72 | $297 | $513 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-15 |
Product Details
| Product Name: iRGD peptide | CAS No.: 1392278-76-0 |
| Purity: 98.77% | Supply Ability: 10g |
| Release date: 2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | iRGD peptide |
| 描述 | iRGD peptide (c(CRGDKGPDC)) is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice. |
| 體外活性 | iRGD peptide-mediated tumor penetration involves a three-step process: initial binding to αv-integrins present on tumor vasculature or cells, the revelation of a C-terminal motif capable of binding to neuropilin-1 (NRP-1) through proteolysis, and subsequent cell internalization. Incorporation of the iRGD peptide into the ICOVIR15K fiber's C terminus specifically improves binding and internalization in MCF7 cells, known to express NRP-1 and integrins, without affecting the virus's ability to infect and replicate[1]. Alone, the iRGD peptide does not significantly impact gastric cancer cells. However, when combined with 5-FU, it notably enhances the chemotherapy's efficacy against gastric cancer cells via NRP1, at a concentration of 0.3 μmol/mL[2]. |
| 體內(nèi)活性 | iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. In vivo, iRGD did not alter the normal organ transduction pattern, with liver and spleen as main targeted organs. iRGD (4 mmol/kg, i.v.) combined with 5-FU significantly suppresses tumor growth in nude mice bearing human gastric cancer cells[2]. |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : Insoluble H2O : 10 mM |
| 關(guān)鍵字 | inhibit | Inhibitor | Integrin | iRGD peptide |
| 相關(guān)產(chǎn)品 | K34c hydrochloride | E7820 | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Cyclo(-RGDfK) | Tirofiban | Bestatin hydrochloride | ICAM-1-IN-1 | Gantofiban |
| 相關(guān)庫 | 半胱氨酸共價化合物庫 | 大環(huán)化合物庫 | 環(huán)肽庫 | 經(jīng)典已知活性庫 | 多肽分子庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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