IRAK4-IN-1 NEW
| Price | $64 | $155 | $239 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: IRAK4-IN-1 | CAS No.: 1820787-94-7 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | IRAK4-IN-1 |
| 描述 | IRAK4-IN-1 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
| 動(dòng)物實(shí)驗(yàn) | In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured. |
| 體外活性 | The in vitro metabolic stability profile of IRAK4-IN-1 was assessed, yielding an EC50 of 2300 nM in rat whole blood (RWB). |
| 體內(nèi)活性 | Oral pharmacokinetic analyses of IRAK4-IN-1 indicate that it possesses a high bioavailability of 73%, along with low plasma clearance (Clp=22 mL/min/kg), which culminates in a stable half-life of 1.3 hours. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 1 mg/ml, Sonication is recommended. H2O : < 0.1 mg/mL (insoluble) |
| 關(guān)鍵字 | IRAK4-IN-1 | inhibit | IRAK4 IN 1 | Inhibitor | IL-1R associated kinase | Interleukin-1 receptor associated kinase | IRAK4IN1 | IRAK-4-IN-1 | IRAK |
| 相關(guān)產(chǎn)品 | IRAK inhibitor 2 | IRAK inhibitor 1 | IRAK-1-4 Inhibitor I | IRAK-4 protein kinase inhibitor 2 | ANTHRAQUINONE-2-CARBOXYLIC ACID | Thalidomide 4-fluoride | IRAK4-IN-20 | GLPG2534 | Zabedosertib | Zimlovisertib | AS-2444697 | JH-X-119-01 |
| 相關(guān)庫 | 高選擇性抑制劑庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 抑制劑庫 | 抗前列腺癌化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗感染化合物庫 | 抗肝癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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