Product Details
| Product Name:
IOX4 |
CAS No.:
1154097-71-8 |
| Purity:
99.97% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | IOX4 |
| 描述 | IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM) |
| 體內(nèi)活性 | IOX4 as a highly potent and selective inhibitor of human PHD2, As shown by studies with mice, IOX4 is useful for in vivo work;?it will then be useful for investigations on the suitability of the PHDs as targets for cerebral diseases such as stroke.?The combined kinetic and biophysical analyses reveal that IOX4 (and IOX2) compete with 2OG for binding to PHD2;?the triazole rings of the inhibitors bind in the pocket occupied by the CH2CH2COOH side chain of 2OG.?The results thus reveal the potential of non-acid containing PHD inhibitors—an important finding given the potential of HIFα upregulation mediated by PHD inhibition in the treatment of stroke, as acids do not often permeate the blood-brain barrier efficiently[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 83.33 mg/mL (253.80 mM), Sonication is recommended.
|
| 關(guān)鍵字 | HIF-PH | HIFs | Hypoxia-inducible factors | inhibit | IOX 4 | IOX4 | HIF/HIF Prolyl-Hydroxylase | Inhibitor | IOX-4 |
| 相關(guān)產(chǎn)品 | Deferoxamine Mesylate | Hydralazine hydrochloride | 1,4-DPCA | DMOG | Chlorogenic Acid | Roxadustat | Glucosamine | Hydroxycitric acid tripotassium hydrate | Glucosamine hydrochloride | Minocycline hydrochloride | Oltipraz | Glucosamine sulfate |
| 相關(guān)庫(kù) | 糖酵解化合物庫(kù) | 細(xì)胞重編程化合物庫(kù) | 糖代謝化合物庫(kù) | 抗胰腺癌化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 谷氨酰胺代謝化合物庫(kù) | 抑制劑庫(kù) | 代謝化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States