Product Details
Product Name:
inS3-54A18 |
CAS No.:
328998-53-4 |
Purity:
99.54% |
Supply Ability:
10g |
Release date:
2024/11/14 |
Product Introduction
Bioactivity
名稱 | inS3-54A18 |
描述 | inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects. |
體外活性 | inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin. |
體內(nèi)活性 | inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 150 mg/mL (401.25 mM)
|
關(guān)鍵字 | Inhibitor | inS-3-54A18 | inS3 54A18 | inS3-54A18 | inS354A18 | inhibit | STAT |
相關(guān)產(chǎn)品 | Nifuroxazide | Balsalazide sodium hydrate | Fludarabine | Scutellarin | Niclosamide | 2-(1,8-naphthyridin-2-yl)phenol | CASIN | Diosgenin | Niclosamide olamine | Artesunate | Alantolactone | Stattic |
相關(guān)庫 | 抗結(jié)直腸癌化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗肝癌化合物庫 | 抗癌活性化合物庫 | 轉(zhuǎn)錄因子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |