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Postion:Product Catalog >inS3-54A18
inS3-54A18
  • inS3-54A18

inS3-54A18 NEW

Price $59 $94 $163
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: inS3-54A18 CAS No.: 328998-53-4
Purity: 99.54% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱inS3-54A18
描述inS3-54A18 is an effective inhibitor of STAT3. inS3-54A18 has anticancer effects.
體外活性inS3-54A18 selectively impedes STAT3's interaction with its inherent target sequences and diminishes the expression of genes downstream of STAT3. It significantly reduces the wound healing capacity in A549 and MDA-MB-231 cells to 64% and 76% at a concentration of 5μM, and further decreases healing to 47% and 39%, respectively, at 10μM. Notably, inS3-54A18 does not interfere with either the basal or IL-6-stimulated activation of STAT3, but specifically inhibits the expression of a STAT3 target gene, survivin.
體內(nèi)活性inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis, and STAT3 target gene expression in an A549 cell mouse xenograft model[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 150 mg/mL (401.25 mM)
關(guān)鍵字Inhibitor | inS-3-54A18 | inS3 54A18 | inS3-54A18 | inS354A18 | inhibit | STAT
相關(guān)產(chǎn)品Nifuroxazide | Balsalazide sodium hydrate | Fludarabine | Scutellarin | Niclosamide | 2-(1,8-naphthyridin-2-yl)phenol | CASIN | Diosgenin | Niclosamide olamine | Artesunate | Alantolactone | Stattic
相關(guān)庫抗結(jié)直腸癌化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗肝癌化合物庫 | 抗癌活性化合物庫 | 轉(zhuǎn)錄因子庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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