Product Details
Product Name:
Indophagolin |
CAS No.:
1207660-00-1 |
Purity:
99.76% |
Supply Ability:
10g |
Release date:
2024/11/18 |
Product Introduction
Bioactivity
名稱 | Indophagolin |
描述 | Indophagolin is a potent, indoline-containing autophagy inhibitor with an IC50 of 140 nM, and it antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40, and 3.49 μM, respectively. |
體外活性 | Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells and antagonizes Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). It also exhibits a strong antagonistic effect on the serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on the 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7 receptors. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 25 mg/mL (47.73 mM)
|
關鍵字 | Indophagolin | inhibit | formation | Inhibitor | 5-hydroxytryptamine Receptor | autophagosome | Serotonin Receptor | P2XRs | P2X Receptor | 5-HT Receptor | membrane-bound | indoline-based | class | Autophagy |
相關產(chǎn)品 | Stavudine | Xylitol | Alverine citrate | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
相關庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 疼痛相關化合物庫 | 神經(jīng)信號分子庫 | 膜蛋白靶向化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 離子通道庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |