INCB 3284 NEW
| Price | $51 | $81 | $137 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-11 |
Product Details
| Product Name: INCB 3284 | CAS No.: 887401-92-5 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2024/11/11 |
Product Introduction
Bioactivity
| 名稱 | INCB 3284 |
| 描述 | INCB 3284 is an orally available, selective and high affinity chemokine receptor 2 (CCR2) antagonist that inhibits monocyte chemotactic protein 1 from interacting with hCCR2.INCB 3284 is used in the study of hemorrhagic shock. |
| 體外活性 | INCB3284 exhibited an IC50 of 3.7 nM for antagonizing the binding of monocyte chemoattractant protein-1 to hCCR2, an IC50 of 4.7 nM for antagonizing chemotactic activity, and an IC50 of 84 μM for inhibiting hERG potassium currents[1]. |
| 體內(nèi)活性 | INCB 3284 (1 mg/kg/day, intraperitoneal injection) or C021 significantly improved the neurological outcomes in AOM-treated mice, reduced microglial activation, decreased phosphorylation of ERK1/2, and attenuated the upregulation of cytokines induced by AOM[2]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 0.1 mg/mL (insoluble) DMSO : 60 mg/mL (115.26 mM), Sonication is recommended. |
| 關(guān)鍵字 | INCB-3284 | INCB3284 | INCB 3284 |
| 相關(guān)產(chǎn)品 | Aplaviroc | AZD2098 | MLN-3897 TFA | CCR2 antagonist 5 | INCB-9471 | CCR3 antagonist 1 | BMS-817399 | PF-4136309 | C-021 | Pirfenidone | Vercirnon | CCR6 antagonist 1 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 細(xì)胞因子抑制劑庫(kù) | 抑制劑庫(kù) | 腫瘤免疫治療小分子化合物庫(kù) | 口服活性化合物庫(kù) | 免疫/炎癥分子化合物庫(kù) | 已知活性化合物庫(kù) | 含氟化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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