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Postion:Product Catalog >IMS2186
IMS2186
  • IMS2186

IMS2186 NEW

Price $38 $58 $136
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: IMS2186 CAS No.: 1031206-36-6
Purity: 99.79% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameIMS2186
DescriptionIMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the amount of eye leakage and diseased cells with no intraocular toxicity.
In vitroIMS2186 (0.3-10 μM; 22 h) inhibits the proliferation of human fibroblasts and human cancer cells with IC50 values of 1.0-3.0 μM and 0.3-3.0 μM, respectively. IMS2186 (0-10 μM; 22 h) also inhibits endothelium formation with an IC50 of 0.1-0.3 μM under 10 ng/mL VEGF stimulation. Additionally, IMS2186 (0.1-10 μM; 24 h) inhibits the production of pro-inflammatory cytokines PGE2/TNF-a in macrophages with an IC50 of 0.3-1 μM, and it inhibits macrophage migration with an IC50 of 1 μM within 1.5 hours[1].
In vivoIMS2186 (2.5 mg in 0.5 mL; vitreous injection; single dose) was administered to rabbit eyes with no ocular toxicity, and IMS2186 (100 μg/eye, i.e. 50 μg/μL solution dosage 2.0 μL; single dose) exhibited an anti-proliferative effect on the rat model of laser-induced choroidal neovascularization (CNV) [1].
StorageShipping with blue ice.
Solubility InformationDMSO : 60 mg/mL (202.48 mM), Sonication is recommended.
KeywordsIMS 2186 | IMS-2186 | IMS2186
Related Compound LibrariesBioactive Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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