IGF-1 LR3, or Insulin-like Growth Factor 1 Long Arg3, is a modified form of the naturally occurring IGF-1 hormone. This synthetic version has been altered to include an extra arginine molecule at the third position of its amino acid sequence and has a substitution that prevents it from binding to IGF-1 binding proteins in the body. These modifications extend the hormone’s half-life and enhance its activity compared to regular IGF-1.

Key Properties and Uses of IGF-1 LR3:

1. Enhanced Potency and Duration: IGF-1 LR3 is more potent and has a longer half-life in the body compared to native IGF-1, due to its reduced affinity for binding proteins which normally inhibit the biological actions of IGF-1.

2. Muscle Growth and Repair: The primary use of IGF-1 LR3 is to promote muscle growth and repair. It stimulates both the differentiation and proliferation of muscle cells, enhances amino acid uptake, and increases protein synthesis in muscle tissues.

3. Research Applications: In scientific research, IGF-1 LR3 is used to study its effects on cell cultures and animal models, particularly looking at muscle growth, regeneration, and aging processes.

4. Bodybuilding and Athletic Enhancement: Due to its muscle-building properties, IGF-1 LR3 is popular in bodybuilding and sports where increased muscle mass and recovery are beneficial. However, its use is controversial and banned in professional sports under anti-doping regulations.

5. Potential Therapeutic Applications: There is interest in using IGF-1 LR3 for treating muscle wasting diseases, such as muscular dystrophy, and conditions associated with aging, such as sarcopenia. However, its use in clinical settings is still under investigation and not yet approved.

Administration and Dosage:

• Administration: IGF-1 LR3 is typically administered through subcutaneous injections to maximize absorption and activity.

• Dosage: The dosage can vary widely depending on the individual's body weight, the specific goals of use, and the advice of a healthcare professional. It is crucial to use this substance under medical supervision due to its potent effects and potential side effects.

Considerations and Warnings:

• Side Effects: Potential side effects include hypoglycemia, swelling, pain at the injection site, and possible increased risk of certain cancers, given IGF-1’s role in cell proliferation.

• Regulatory Status: The use of IGF-1 LR3 in sports and its sale as a dietary supplement are regulated in many jurisdictions, and it is considered a performance-enhancing drug by many sports organizations.

IGF-1 LR3 is a powerful derivative of the IGF-1 hormone, carrying significant implications for muscle growth and development. Its use, particularly outside of approved medical and research settings, should be approached with caution due to its powerful biological effects and potential legal implications.