Icaritin NEW
Price | $200 | $1 |
Package | 1KG | 100KG |
Min. Order: | 1KG |
Supply Ability: | g-kg-tons, free sample is available |
Update Time: | 2024-01-02 |
Product Details
Product Name: Icaritin | CAS No.: 118525-40-9 |
Min. Order: 1KG | Purity: 99%, 99.5% Sublimated |
Supply Ability: g-kg-tons, free sample is available | Release date: 2024/01/02 |
Lead time: In stock | Packaging: bottle/drum/bucket/IBC |
Delivery: By sea,by air,by express | Origin: Manufacturer |
Category: Heterocycles compounds; OLED intermediates |
1. Materials information
Use of Icaritin
Icaritin(Anhydroicaritin) is a component of Epimedium flavonoid isolated from Herba Epimedii; enhances osteoblastic differentiation of mesenchymal stem cells (MSCs) while it inhibits adipogenic differentiation of MSCs by inhibiting PPAR-g pathway.IC50 value:Target: in vitro: Icaritin was unable to promote proliferation, migration and tube like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro [1]. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis [2]. icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression [3].in vivo: In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner [2].
Density | 1.4±0.1 g/cm3 |
---|---|
Boiling Point | 582.0±50.0 °C at 760 mmHg |
Melting Point | 239oC |
Molecular Formula | C21H20O6 |
Molecular Weight | 368.380 |
Flash Point | 206.7±23.6 °C |
Exact Mass | 368.125977 |
PSA | 100.13000 |
LogP | 4.84 |
Appearance of Characters | light yellow to dark yellow |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.657 |
Storage condition | 2-8°C |
Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: elin@fdachem.com
Mob: 86 13613820652
WhatsApp/Skype/Wechat/LINE: 86 13613820652
Company Profile Introduction
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- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro