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Postion:Product Catalog >API>Antiparasitic drugs>Antimalarial drugs>Hydroxychloroquine sulfate
Hydroxychloroquine sulfate
  • Hydroxychloroquine sulfate

Hydroxychloroquine sulfate NEW

Price $48 $74
Package 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Hydroxychloroquine sulfate CAS No.: 747-36-4
Purity: 99.88% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameHydroxychloroquine sulfate
DescriptionHydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
Cell ResearchAll cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference)
Kinase AssayIn vitro kinase assays: with purified proteins, recombinant S6 protein and recombinant active P70S6K are incubated in 1x kinase buffer with various amount of HCQ or RAD001 in the presence (25 μM) or absence of ATP for 30 minutes at 30°C. Total and phosphorylated S6 at ser235/236 and ser240/244 are detected by western analysis using phosphospecific antibodies. Note that recombinant GST-tagged S6 (53 kd) is distinguished from endogenous S6 (32 kd) on the western blot.
In vitroHydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis[2].
In vivoThe treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent[3]. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals[4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Insoluble
H2O : 10 mM
KeywordsHCQ | Inhibitor | Toll-like Receptor (TLR) | SARS-CoV | Autophagy | SARS coronavirus | Hydroxychloroquine | Hydroxychloroquine sulfate | inhibit | Hydroxychloroquine Sulfate | Parasite | HCQ Sulfate
Inhibitors RelatedHydroxychloroquine
Related Compound LibrariesBioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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