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Postion:Product Catalog >Natural Products>Flavonoids>Hinokiflavone
Hinokiflavone
  • Hinokiflavone

Hinokiflavone NEW

Price $39 $113 $168
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Hinokiflavone CAS No.: 19202-36-9
Purity: 98.67% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameHinokiflavone
DescriptionHinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO protease inhibitor by impeding the activity of sentrin-specific protease 1 (SENP1). Hinokiflavone also demonstrates significant cytotoxicity, including the inhibition of MMP-9.
In vitroHinokiflavone exhibited a time- and dose-dependent manner apoptosis induction by upregulating expression of Bax and downregulating Bcl-2 in breast cancer cells.?Furthermore, hinokiflavone significantly inhibited the migration and invasion of breast cancer cells by impairing the process of epithelial-to-mesenchymal transition.?The tumour growth was distinctly inhibited by treatment of hinokiflavone in a xenograft tumour mouse model of MDA-MB-231 cells.?Immunohistochemical analysis of tumour sections showed that MMP-2+ cells and Ki-67+ cells were remarkably decreased in tumour tissues of mice after treatment of hinokiflavone, indicating that hinokiflavone inhibits not only proliferation but also metastasis of breast cancer cells.Hinokiflavone can be a potential drug to breast cancer[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Slightly soluble
KeywordsHinokiflavone | E2 conjugating enzyme | E3 ligating enzyme | E1 activating enzyme | Ubiquitin ligase | Ubiquitin conjugating enzyme | E1/E2/E3 Enzyme | Ubiquitin activating enzyme | inhibit | Inhibitor
Inhibitors RelatedStigmasterol | (S)-(+)-Ibuprofen | Doxycycline (hyclate) | Astragaloside IV | Doxycycline | Navitoclax | Edaravone | Glucosamine | Bovine Type II Collagen | Venetoclax | Indole-3-carbinol | Glucosamine sulfate
Related Compound LibrariesAnti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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