Hemokinin 1 (mouse) acetate(208041-90-1 free base) NEW
| Price | $143 | $412 | $613 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Hemokinin 1 (mouse) acetate(208041-90-1 free base) | Purity: 98.33% |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Hemokinin 1 (mouse) acetate(208041-90-1 free base) |
| Description | Hemokinin 1 (mouse) acetate is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor. |
| In vitro | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB[1]. |
| In vivo | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Hemokinin 1 (mouse) acetate(208041901 free base) | Hemokinin 1 (mouse) acetate(208041 90 1 free base) | Hemokinin 1 acetate(208041-90-1 free base) |
| Inhibitors Related | Rolapitant | Ezlopitant | (R)-CJ 11974 | N-Acetyl-L-tryptophan | Netupitant | Aprepitant | Befetupitant | Vofopitant | Fosaprepitant dimeglumine | Maropitant |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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