Gypenoside XLVI NEW
| Price | $59 | $143 | $213 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Gypenoside XLVI | CAS No.: 94705-70-1 |
| Purity: 98.59% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Gypenoside XLVI |
| 描述 | Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml. |
| 體外活性 | Gynostemma pentaphyllum (Thunb.) Makino is one of the well-known traditional Chinese herbal medicines, which has been demonstrated to be effective against chronic diseases, such as lung cancer. In the present study, seven dammarane-type compounds were isolated from the raw, heat processed and alkaline hydrolyzed G. Pentaphyllum and compared for their cytotoxic activities against non-small cell lung carcinoma A549 cells using MTT cytotoxicity assay. METHODS AND RESULTS: By means of chemical and spectroscopic methods, their structures were established as gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α, 3β, 12β, 20-tetrol. Gypenoside LVI, Gypenoside XLVI, gypenoside L, gypenoside LI, damulin A, damulin B and 20S-dammar-24-en-2α,3β,12β,20-tetrol all showed strong cytotoxic activity against A549 cells, with the IC50 values of 105.89±2.48, 52.63±8.31, 34.94±4.23, 50.96±9.55, 26.98±0.51, 4.56±0.58, 12.54±0.53 μg/ml respectively, whereas the IC50 value of 20S-Rg3 (positive control) was 55.36±3.20 μg/ml. Comparing their structures with cytotoxic activity, these compounds might possess some kind of structure-activity relationship. CONCLUSIONS: Based on the structure and cytotoxic activity relationships of these seven constituents, the OH group in C-2, the double bond in C20(21) and C20(22) positions, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (25.96 mM) |
| 關(guān)鍵字 | inhibit | Inhibitor | Gypenoside XLVI |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 經(jīng)典已知活性庫(kù) | 中藥單體化合物庫(kù) | 稀有天然產(chǎn)物庫(kù) | 植物來源化合物庫(kù) | 苗藥化合物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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