Product Details
Product Name:
GW-870086 |
CAS No.:
827319-43-7 |
Purity:
99.63% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | GW-870086 |
Description | GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB). |
In vitro | GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2)[1]. GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin[2]. GW-870086 (GW870086X; 10-100 nM) obviously increases fibronectin secretion. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 11 mg/mL (19.66 mM)
|
Keywords | GW-870086 | Glucocorticoid Receptor | GW870086 | Inhibitor | GW 870086 | inhibit |
Inhibitors Related | Nimodipine | Hydrocortisone | Mifepristone | Prednisolone acetate | Beclometasone | Cortisone | Dexamethasone acetate | Prednisolone | Dexamethasone Phosphate disodium | Prednisone acetate | Desonide | Corticosterone |
Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:220904-83-6
$36.00 / 2mg
-
CAS:253124-46-8
$154.00 / 1mg
-
CAS:278779-30-9
$46.00 / 5mg
Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$0.00/1G |
VIP1Y
|
CONTIDE BIOTECH CO.,LTD
|
2024-04-12 |
|
$0.00/25g |
VIP1Y
|
Wuhan Circle Star Chem-medical Technology Co.,Ltd
|
2025-01-03 |
|
$50.00/1kg |
VIP2Y
|
Hebei Miaoyin Technology Co.,Ltd
|
2023-03-09 |