Guanidinosuccinic acid NEW
| Price | $35 | $35 | $48 | $48 | $85 | $85 |
| Package | 25mg | 25mg | 50mg | 50mg | 100mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: Guanidinosuccinic acid | CAS No.: 6133-30-8 |
| Purity: ≥95% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | Guanidinosuccinic acid |
| 描述 | Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine. |
| 體內(nèi)活性 | Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 6 mg/mL (34.26 mM) DMSO : 75 mg/mL (428.23 mM) |
| 關鍵字 | Guanidinosuccinic acid | Inhibitor | Endogenous Metabolite | inhibit |
| 相關產(chǎn)品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
| 相關庫 | 經(jīng)典已知活性庫 | 天然產(chǎn)物庫 | 高通量篩選天然產(chǎn)物庫 | 人內(nèi)源代謝化合物庫 | 已知活性化合物庫 | 腸道微生物代謝化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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