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Postion:Product Catalog >GSK2239633A
GSK2239633A
  • GSK2239633A

GSK2239633A NEW

Price $32 $76 $127
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-08

Product Details

Product Name: GSK2239633A CAS No.: 1240516-71-5
Purity: 99.78% Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱GSK2239633A
描述GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.
體外活性GSK2239633A increases the CCL17-induced F-actin content of human CD4+ CCR4+ T cells with a pEC50 value of 8.79±0.22[1]. GSK2239633A inhibits thymus- and activation-regulated chemokine-induced (TARC)-induced increases in the F-actin content of isolated human CD4+ CCR4+ T-cells with a pA2 of 7.11±0.29[3].
體內(nèi)活性GSK2239633A demonstrates good pharmacokinetic data in preclinical animal studies with bioavailability in rats and beagle dogs of 85% and 97% respectively[2]. Plasma GSK2239633A (i.v.) displays rapid, bi-phasic distribution and slow terminal elimination (13.5 h), suggesting that GSK2239633A is a low to moderate clearance drug. Blood levels of GSK2239633A(oral) reach Cmax rapidly (median tmax: 1.0-1.5 hours)[3].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 250 mg/mL (455.32 mM)
關(guān)鍵字GSK-2239633A | inhibit | Inhibitor | CC chemokine receptor | GSK2239633A | CCR
相關(guān)產(chǎn)品AZD2098 | MLN-3897 TFA | Artemotil | CCR2 antagonist 5 | INCB-9471 | CCR3 antagonist 1 | Maraviroc | BMS-817399 | PF-4136309 | Pirfenidone | Vercirnon | CCR6 antagonist 1
相關(guān)庫經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | ReFRAME 相關(guān)化合物庫 | 抑制劑庫 | 腫瘤免疫治療小分子化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$32.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-07
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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