GNF-PF-3777 NEW
| Price | $46 | $124 | $187 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: GNF-PF-3777 | CAS No.: 77603-42-0 |
| Purity: 97.88% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | GNF-PF-3777 |
| 描述 | GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM. |
| 體外活性 | GNF-PF-3777 (Compound 5i) is a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity (EC50: 0.82 μM) [2]. GNF-PF-3777 has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogs lack LORA activity [3]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 1 mg/mL, Sonication is recommended. |
| 關(guān)鍵字 | GNFPF3777 | GNF-PF 3777 | GNF PF 3777 | Inhibitor | inhibit | Indoleamine 2,3-Dioxygenase (IDO) | GNF-PF3777 | GNF-PF-3777 |
| 相關(guān)產(chǎn)品 | Palmatine chloride | Coptisine chloride | Necrostatin-1 | IDO-IN-7 | IDO1-IN-1 | Indoximod | Palmatine | IDO inhibitor 1 | Epacadostat | β-Lapachone | IDO5L | IDO-IN-12 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抗癌細(xì)胞代謝庫(kù) | 抑制劑庫(kù) | NO PAINS 化合物庫(kù) | 腫瘤免疫治療小分子化合物庫(kù) | 代謝化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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