Glycocholic acid NEW
| Price | $34 | $1.2 |
| Package | 1kg | 1000kg |
| Min. Order: | 1kg |
| Supply Ability: | g-kg-tons, free sample is available |
| Update Time: | 2024-04-05 |
Product Details
| Product Name: Glycocholic acid | CAS No.: 475-31-0 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: g-kg-tons, free sample is available | Release date: 2024/04/05 |
| Lead time: In stock, ready for shipment | In stock, ready for shipment: bag/bottle/drum/IBC |
| bag/bottle/drum/IBC: By express, by air, by sea | Origin: Manufacturer, advantage product |
| COA, MSDS: Available, contact us for details | Name: Mia |
1. Materials information
| Name | glycocholic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. |
|---|---|
| Related Catalog | Signaling Pathways >> Apoptosis >> Bcl-2 Family Natural Products >> Acids and Aldehydes Research Areas >> Cancer |
| Target | Human Endogenous Metabolite Bax Bcl-2 MDR1 MRP1 MDR2 |
| In Vitro | Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1]. |
| References | [1]. Lo YL, et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci. 2008 Sep 2;35(1-2):52-67. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 655.3±65.0 °C at 760 mmHg |
| Melting Point | 128°C |
| Molecular Formula | C26H43NO6 |
| Molecular Weight | 465.623 |
| Flash Point | 350.1±34.3 °C |
| Exact Mass | 465.309052 |
| PSA | 127.09000 |
| LogP | 2.45 |
| Vapour Pressure | 0.0±4.5 mmHg at 25°C |
| Index of Refraction | 1.645 |
| Storage condition | Refrigerator |
| Water Solubility | methanol: 0.1 g/mL, clear, colorless |
| Hazard Codes | N:Dangerousfortheenvironment; |
|---|---|
| Risk Phrases | R51/53 |
| Safety Phrases | S61 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
By Express
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
By Air
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
By Sea
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
For more details, pls contact us freely.
Email address: mia@fdachem.com
Mob: 86 18336764634
WhatsApp/Skype/Wechat/LINE: 86 18336764634
Company Profile Introduction
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China
- Since: 2023-02-10
- Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro