Geniposide NEW
| Price | $60 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Geniposide | CAS No.: 24512-63-8 |
| Purity: 99.54% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Geniposide |
| 描述 | Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation. |
| 細(xì)胞實(shí)驗(yàn) | The third passages of brain microvascular endothelial cells (BMECs) are used for the experiment. The BMECs are divided into four groups: (1)normal control group: the normal cultured BMECs without treatment; (2)OGD group: the BMECs injured by OGD according to the above method; (3) geniposide group: the OGD-injured BMECs treated with 33.2 μg/mL geniposide for 6 h; (4)PTX group: the OGD-injured BMECs administrated with 100 ng/mL PTX. PTX, known as an inhibitor of Gi-coupled receptor is used to assess the activation of P2Y14 receptor induced by OGD in this experiment[2]. |
| 體外活性 | Geniposide demonstrates multifaceted bioactivities, including antithrombotic, anti-inflammatory, antidiabetic, anti-atherosclerotic, antidepressant effects, and therapeutic potential for Alzheimer's disease (AD), anti-hypertensive, and toxicological effects, alongside managing adverse reactions[1]. It significantly reduces IL-8, IL-1β, and MCP-1 production in OGD-induced brain microvascular endothelial cells, markedly downregulates P2Y14 receptor expression, and inhibits the phosphorylation of RAF-1, MEK1/2, and ERK1/2[2]. |
| 體內(nèi)活性 | Geniposide, administered at doses of 200 and 400 mg/kg, has been observed to significantly reduce blood glucose, insulin, and triglyceride (TG) levels in a dose-dependent manner in diabetic mice. Additionally, it diminishes the expression and enzymatic activity of glucose-6-phosphatase (G6Pase) and glycogen phosphorylase (GP) at both mRNA and protein levels. At dosages of 20.0, 40.0, or 80 mg/kg, geniposide effectively counters the excessive elevation of serum alanine transaminase/aspartate transaminase (ALT/AST) and hepatic lipid peroxidation (LPO) levels induced by alcohol, signifying its potent hepatoprotective properties. Furthermore, it enhances the expression of heme oxygenase-1 (HO-1), mitigating cell apoptosis in primary cultured hippocampal neurons caused by 3-morpholinosydnonimine hydrochloride (SIN-1). In addition to its neuroprotective and hepatoprotective effects, geniposide exhibits anti-thrombotic activity in a photochemistry-induced thromboembolism model in vivo and acts as an effective inhibitor of Nuclear Factor kappa B (NF-κB) activity by preventing IκB degradation. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (128.74 mM) |
| 關(guān)鍵字 | β-amyloid peptide | Inhibitor | Geniposide | inhibit | Amyloid-β | Influenza Virus | Abeta |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗病毒庫 | 天然產(chǎn)物庫 | 苗藥化合物庫 | 藥物功能重定位化合物庫 | 糖類及苷類化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抗病毒中藥單體化合物庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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