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Postion:Product Catalog >G244-LM
G244-LM
  • G244-LM

G244-LM NEW

Price $44 $98 $178
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: G244-LM CAS No.: 1563007-08-8
Purity: 98.46% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameG244-LM
DescriptionG244-LM, a potent and specific inhibitor of tankyrase 1/2, effectively inhibits Wnt signaling.
In vitroG244-LM is a potent and specific small-molecule tankyrase inhibitors, that reduce Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.?The novel tankyrase inhibitors completely block ligand-driven Wnt/β-catenin signaling in cell culture and display approximately 50% inhibition of APC mutation-driven signaling in most CRC cell lines.?It was previously unknown whether the level of AXIN protein stabilization by tankyrase inhibition is sufficient to impact tumor growth in the absence of normal APC activity.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 5 mM
KeywordsInhibitor | G244LM | inhibit | poly ADP ribose polymerase | PARP | G244 LM | G244-LM | G-244-LM
Inhibitors Related4'-Methoxychalcone | Niraparib tosylate monohyrate | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | 3-Methoxybenzamide | NU1025 | Olaparib | Benzamide | Picolinamide | OUL35
Related Compound LibrariesBioactive Compound Library | Epigenetics Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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