Chinese name: N-(9-fluorene methoxycarbonyl) -n-methyl-L-phenylalanine

English name: Fmoc-N-methyl-L-phenylalanine

CAS: 77128-73-5

Molecular formula: C25H23NO4

MDL number: MFCD00151938

Molecular weight: 401.45

Melting point: 132.0 to 136.0 °C

Boiling point: 595.4±39.0 °C(Predicted)

Density: 1.260± 0.06g /cm3(Predicted)

Storage conditions: 2-8°C

Solubility: Dissolved in DMF. (0.3 g/ml)

Acidity coefficient (pKa) : 3.78±0.10(Predicted)

Form: Powder

Color: beige

optical activity: [α]20/D 55.0±3°, c = 1% in DMF

BRN: 4768138

InChIKey: GBROUWPNYVBLFO-QHCPKHFHSA-N

Nature:

- Appearance: white or white crystal

- Solubility: soluble in certain organic solvents such as methanol, dichloromethane and ether solvents.

Purpose:

Fmoc-Me-L-Phe-OH is often used in peptide synthesis as an amino acid protection group, which protects the amino functional groups of amino acids to prevent unnecessary reactions. It is also used as an important component of building polypeptide chains, especially in solid phase synthesis.

Preparation:

The preparation of Fmoc-Me-L-Phe-OH is usually done by reacting Fmoc-Cl (9-fluorene formyl chloride) with methyl-L-phenylalanine. The reaction needs to be carried out under alkaline conditions and the resulting product can then be purified by crystallization to obtain a pure product