Flupirtine maleate NEW
| Price | $45 | $56 | $77 |
| Package | 10mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Flupirtine maleate | CAS No.: 75507-68-5 |
| Purity: 99.9% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱(chēng) | Flupirtine maleate |
| 描述 | Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener. |
| 細(xì)胞實(shí)驗(yàn) | For measurement of viability and generation of reactive oxygen intermediates, PC12 cells are seeded in 24- or 96-well plates coated with poly-L-lysine at 105 cells/mL. Drugs are dissolved in PBS (pH 7.4), or ethanol and filtered sterile. At the end of each experiment cells are trypsinized and pelleted together with cells of the culture supernatant. After staining for 10 min with 0.2% Trypan blue solution live (unstained) and dead (Trypan blue positive) cells are counted in a hemocytometer chamber. In addition, cellular viability is evaluated by the reduction of MTT to formazan. After 2 hours incubation with MTT (0.5 mg/ml) at 37 °C, cells are lysed in DMSO. Extinction at 570 nm is determined on a plate photometer. For staining of surviving adherent cells, plates are incubated for 10 min with 0.5% crystalviolet dissolved in 20% methanol. Plates are rinsed with water and stained cells are lysed in 50% ethanol, 0.1 M sodiumcitrate before determining extinction at 550 nm. (Only for Reference) |
| 體外活性 | Flupirtine was able to block NMDA and gp120 HIV-1-induced cell death in rat cortical neurons.Flupirtine at concentrations of 1 μM and 10 μM reduced TRAIL-regulated death of human living brain tissue in culture; a concentration of 10 μM in 10 mM L-glutamic acid-treated PC 12 cultures significantly reduced non-receptor- regulated necrotic cell death; a concentration of 1 or 5 μg/mL blocked β-amyloid (25-35)-induced apoptosis by acting on primary neuronal cells; and a concentration of 1-10 mM protected primary neuronal cells from monosodium glutamate-induced toxicity by lowering calcium ion concentration. |
| 體內(nèi)活性 | Flupirtine was able to block NMDA and gp120 HIV-1-induced cell death in rat cortical neurons.Flupirtine at concentrations of 1 μM and 10 μM reduced TRAIL-regulated death of human living brain tissue in culture; a concentration of 10 μM in 10 mM L-glutamic acid-treated PC 12 cultures significantly reduced non-receptor- regulated necrotic cell death; a concentration of 1 or 5 μg/mL blocked β-amyloid (25-35)-induced apoptosis by acting on primary neuronal cells; and a concentration of 1-10 mM protected primary neuronal cells from monosodium glutamate-induced toxicity by lowering calcium ion concentration. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (118.94 mM), Sonication is recommended. Ethanol : 4.2 mg/mL (10 mM) |
| 關(guān)鍵字 | centrally | acting | brain,?penetrant | Flupirtine maleate | KcsA | Flupirtine | Neuroprotective | Inhibitor | inhibit | Ionotropic glutamate receptors | stroke | non-opioid | Katadolon Maleate | Flupirtine Maleate | Potassium Channel | analgesic | iGluR | NMDAR |
| 相關(guān)產(chǎn)品 | Minoxidil sulfate | L-Glutamic acid | glycine | Halothane | L-Glutamic acid monosodium salt | Riluzole | Cloperastine hydrochloride | O-Phospho-L-serine | Indapamide |
| 相關(guān)庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 疼痛相關(guān)化合物庫(kù) | 膜蛋白靶向化合物庫(kù) | EMA 上市藥物庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | 已知活性化合物庫(kù) | 離子通道庫(kù) | 抗癌藥物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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