6α-Fluorodexamethasone is an anti-inflammatory glucocorticoid used in veterinary practice and used as an anti-inflammatory for a variety of animals. It is commonly investigated for its effectiveness in animals to combat inflammatory symptoms caused by pathogens and to better understand inflammatory mechanisms. It is also used as to investigate novel techniques that detect and quantify steroid compounds within muscles.

For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions.

6α-Fluorodexamethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. 6α-Fluorodexamethasone shows fully 420 times the potency of cortiso ne in an animal model for anti-inflammatory activity.

6α-Fluorodexamethasone has been shown to exert anti-inflammtory effects by functioning as a glucocorticoid receptor agonist. Stimulating this receptor promotes inhibition of phospholipase A2 activity. This enzyme catalyzes arachidonic acid into eicosanoids most of which stimulate anti-inflammation mechanisms.

6α-Fluorodexamethasone is a topical corticosteroid of the glucocorticoid class used in the treatment of skin disorders where it reduces inflammation.

6α-Fluorodexamethasone is insoluble in water.

6α-Fluorodexamethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application.

It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.