Fludrocortisone NEW
| Price | $35 | $77 | $123 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Fludrocortisone | CAS No.: 127-31-1 |
| Purity: 98.66% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Fludrocortisone |
| 描述 | Fludrocortisone （Florinef） is a synthetic corticosteroid with moderate glucocorticoid potency and greater mineralocorticoid potency. Fludrocortisone is in research use for the treatment of hypotension.[3] |
| 體外活性 | METHODS: MIO-M1 cells were selected to study the anti-inflammatory effects of Fludrocortisone （Florinef） under IL-1β or TNF-α stimulation. Fludrocortisone was added to the culture medium at a concentration of 1 μg/μl, and 1 ng/μl of IL-1β or TNF-α was added at the same time. RESULTS Fludrocortisone reduced the expression of CCL2, IL-6, and IL-8 to baseline levels after TNF-α stimulation. [2] |
| 體內(nèi)活性 | METHODS: Wistar rats were treated intravenously with Fludrocortisone （Florinef） (5 and 20 μg/kg). The effects of a single dose of fludrocortisone on systolic blood pressure in normal and endotoxemic rats were evaluated until 2 h after treatment injection and in vitro vasoconstriction to phenylephrine in mesenteric artery rings 3 h after treatment. RESULTS Fludrocortisone increased systolic blood pressure (P < 0.001), but more in endotoxemic than in normal animals. Fludrocortisone significantly improved the contractile response to phenylephrine (P = 0.039 and P = 0.007, respectively). [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (144.57 mM) |
| 關(guān)鍵字 | 9alpha-Fluorcortisol | Fludrocortisone | 9alpha-Fludrocortisone | Mineralocorticoid Receptor | 9a-Fludrocortisone | Inhibitor | inhibit | 9a-Fluorcortisol | 9alpha-fluorocortisol | 9alpha-fluorohydrocortisone | Fludrocortisone Acetate | 9a-fluorohydrocortisone | 9a-fluorocortisol |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 兒童藥物庫 | 藥物功能重定位化合物庫 | 口服活性化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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