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Ezatiostat NEW

Price	$31	$65	$113
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-12

Product Details

Product Name: Ezatiostat	CAS No.: 168682-53-9
Purity: 97.95%	Supply Ability: 10g
Release date: 2024/11/12

Product Introduction

Bioactivity

名稱	Ezatiostat
描述	Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
體內(nèi)活性	Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500 mg/day) in combination with 10 mg of lenalidomide on days 1-21 of a 28-day cycle. One of 4 evaluable patients (25%) in the 2500/10 mg dose group experienced an erythroid hematologic improvement (HI-E) response by 2006 MDS International Working Group (IWG) criteria. Four of 10 evaluable patients (40%) in the 2000 mg/10 mg dose group experienced a HI-E response [1]. Systemic inhibition of GSTP1 with Ezatiostat (0-30 mg/kg, i.p.) dose-dependently reduced the reinforcing effects of alcohol as measured by operant self-administration, in the absence of motor effects [2].
存儲條件	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : Insoluble DMSO : >50 mg/mL (94.4 mM) Ethanol : 20 mg/mL (37.76)
關(guān)鍵字	Inhibitor \| lymphocyte \| inhibit \| Glutathione transferases \| TLK 199 \| GSTs \| Gutathione S-transferase \| proliferation \| Apoptosis \| c-Jun \| JNK \| GSTP1 \| TLK-199 \| ERK1 \| MDS \| tripeptide \| Ezatiostat
相關(guān)產(chǎn)品	Stavudine \| Sodium 4-phenylbutyrate \| Tributyrin
相關(guān)庫	經(jīng)典已知活性庫 \| 抗衰老化合物庫 \| 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.