Evocarpine NEW

Price	$83	$197	$297
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-08

Product Details

Product Name: Evocarpine	CAS No.: 15266-38-3
Purity: 99.77%	Supply Ability: 10g
Release date: 2024/11/08

Product Introduction

Bioactivity

名稱	Evocarpine
描述	Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.
體外活性	The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1]
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (147.27 mM)
關(guān)鍵字	Ca2+ \| HL-60 \| inhibit \| antimycobacterial \| Inhibitor \| Evocarpine \| leukaemia \| Bacterial \| Apoptosis \| Influx
相關(guān)產(chǎn)品	Neomycin sulfate \| Sulfamethoxazole sodium \| Tributyrin \| Dimethyl sulfoxide
相關(guān)庫	經(jīng)典已知活性庫 \| 疼痛相關(guān)化合物庫 \| 稀有天然產(chǎn)物庫 \| 膜蛋白靶向化合物庫 \| 植物來源化合物庫 \| 高通量篩選天然產(chǎn)物庫 \| 已知活性化合物庫 \| GPCR靶點(diǎn)分子庫 \| 古代經(jīng)典名方目錄分子庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.