Eupalinolide A NEW
| Price | $66 | $105 | $222 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Eupalinolide A | CAS No.: 877822-40-7 |
| Purity: 99.22% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | Eupalinolide A |
| Description | Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines. |
| In vitro | Eupalinolide B and A (EB and EA) from E. lindleyanum, and describe their actions as HSP-inducers.?EA and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability.?Treatment of cells with EA or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the EA- or EB-mediated induction of HSP70 expression.?Furthermore, EB inhibited the interaction between HSF1 and HSP90, which is known to inhibit the activity of HSF1.?Suggest that EA and EB induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90.?EA and EB both induced the expression of HSP70 synergistically with other stressors.?Furthermore, pre-treatment of cells with EA or EB suppressed melanin production and stressor-induced apoptosis.?These effects were suppressed by the artificial suppression of HSP70 expression.?In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin.[1] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (108.11 mM) |
| Keywords | Eupalinolide A | responses | inflammatory | HSF1 | expression | HSP | Inhibitor | production | UV-induced | melanin | skin | damage | Heat shock proteins | inhibit |
| Inhibitors Related | Tamoxifen | Palmitic acid | Paeoniflorin |
| Related Compound Libraries | 抗癌天然產(chǎn)物庫(kù) | 萜類天然產(chǎn)物庫(kù) | 中藥單體化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 植物來(lái)源化合物庫(kù) | 中藥抗炎分子庫(kù) | 天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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