Product Details
| Product Name:
ELN-441958 |
CAS No.:
913064-47-8 |
| Purity:
98.9% |
Supply Ability:
10g |
| Release date:
2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | ELN-441958 |
| 描述 | ELN-441958 is a potent, neutral antagonist of the B1 receptor, inhibiting the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with a Ki of 0.26 nM. ELN-441958 (ELN 441958) is highly selective for B1 over B2 receptors. |
| 激酶實(shí)驗(yàn) | IGF-IR Peptide Autophosphorylation: One microgram of constitutively active IGF-IR kinase domain peptide isincubated +/? varying concentrations of PQ 401 in 2% DMSO in 40 mM Tris (pH 7.4), 80 μMEGTA, 0.25% 2-mercaptoethanol, 80 μM Na3VO4, 10 mM MgCl2, and 2 mM MnCl2 for 20 minutes. ATP isthen added at a final concentration of 20 μM. Autophosphorylation of the kinase domain peptide isallowed to occur for 20 minutes at 22℃. The reaction isstopped by the addition of SDS-reducing buffer and the samples are run on SDS-PAGE. Following transfer to nitrocellulose membrane, peptide autophosphorylation isdetermined by Western blotting employing an antibody against phosphotyrosine (PY20). |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5.01 mg/mL (10 mM)
|
| 關(guān)鍵字 | low CNS exposure | ELN-441958 | Inhibitor | anti-hyperalgesic | Bradykinin Receptor | inhibit | ELN441958 | high oral bioavailability |
| 相關(guān)產(chǎn)品 | Safotibant | NPC 567 acetate | [Des-Arg9]-Bradykinin acetate | B-Raf IN 14 | Lys-Bradykinin acetate(342-10-9 free base) | Anatibant 2HCl | (Hyp3)-Bradykinin acetate | MK-0686 | Sar-[D-Phe8]-des-Arg9-Bradykinin acetate | R715 TFA(185052-09-9 free base) | 5-Hydroxy-1-methylhydantoin | Lys-[Des-Arg9]Bradykinin acetate |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抗肥胖化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 臨床前化合物庫 | GPCR靶點(diǎn)分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States