Doxapram NEW
| Price | $36 | $76 | $109 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Doxapram | CAS No.: 309-29-5 |
| Supply Ability: 10g | Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Doxapram |
| 描述 | Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of ??prematurity and exacerbation of chronic obstructive pulmonary disease. |
| 體外活性 | Doxapram inhibits TASK-1 (EC50=410 nM), TASK-3 (EC50=37 μM), TASK-1/TASK-3 (EC50=9 μM) heterodimeric channel function. Doxapram also evoked 3H overflow in a concentration dependent manner, and Doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 mM). [1] Doxapram (1-100 mM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50=13 mM). Doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. [2] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 50 mg/mL, (132.10 mM.), Sonication is recommended. DMSO : 50 mg/mL, (132.10 mM.), Sonication is recommended. |
| 關(guān)鍵字 | Doxapram |
| 相關(guān)產(chǎn)品 | Minoxidil sulfate | Quinine | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Tetraethylammonium chloride | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Chlorzoxazone | Indapamide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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