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Postion:Product Catalog >Dipraglurant
Dipraglurant
  • Dipraglurant

Dipraglurant NEW

Price $98 $239 $347
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: Dipraglurant CAS No.: 872363-17-2
Purity: 98.7% Supply Ability: 10g
Release date: 2024/11/06

Product Introduction

Bioactivity

名稱Dipraglurant
描述Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model.
體外活性The novel mGlu receptor negative allosteric modulator (NAM) bifunctional agent Dipraglurant(1-10 μM; 15 minutes) counteracted the abnormal membrane responses and calcium elevations induced by the D2R agonist quinpirole or (NPEC-dopamine) in both models[2].
體內(nèi)活性Dipraglurant (3-30 mg/kg; single oral dose) exhibits favorable pharmacokinetics and reduces levodopa-induced dyskinesia and muscle tone disturbances without interfering with the efficacy of levodopa treatment in parkinsonian disabled monkeys [1].
存儲(chǔ)條件store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 40 mg/mL (150.78 mM)
關(guān)鍵字Dipraglurant | ADX-48621 | ADX 48621
相關(guān)產(chǎn)品IDRA-21 | Decanoic Acid | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | 已知活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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