Product Details
Product Name:
Dipraglurant |
CAS No.:
872363-17-2 |
Purity:
98.7% |
Supply Ability:
10g |
Release date:
2024/11/06 |
Product Introduction
Bioactivity
名稱 | Dipraglurant |
描述 | Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model. |
體外活性 | The novel mGlu receptor negative allosteric modulator (NAM) bifunctional agent Dipraglurant(1-10 μM; 15 minutes) counteracted the abnormal membrane responses and calcium elevations induced by the D2R agonist quinpirole or (NPEC-dopamine) in both models[2]. |
體內(nèi)活性 | Dipraglurant (3-30 mg/kg; single oral dose) exhibits favorable pharmacokinetics and reduces levodopa-induced dyskinesia and muscle tone disturbances without interfering with the efficacy of levodopa treatment in parkinsonian disabled monkeys [1]. |
存儲(chǔ)條件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 40 mg/mL (150.78 mM)
|
關(guān)鍵字 | Dipraglurant | ADX-48621 | ADX 48621 |
相關(guān)產(chǎn)品 | IDRA-21 | Decanoic Acid | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
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Suppliers |
Update time |
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$15.00/1KG |
|
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 |
|
$15.00/1KG |
|
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 |