Manufacturer Provide Veterinary Drugs CAS536-71-0 Diminazene Aceturate

Introduction

Product Name: Diminazene Aceturate

Other Name :4,4'-(1,3-Triazenediyl)bis(benzamidine);4,4'-(Azoimino)bis(benzamidine);4,4'-(Diazoamino)dibenzamidine;4-[(4-Amidinophenylazo)amino]benzamidine

C.A.S NO. :536-71-0

Assay (%)(HPLC, Basis on drying):99%

Molecular formula: C14H15N7

Appearance: Yellow Powder

Molecular weight :281.32

Boiling Point :463.3±55.0 °C(Predicted)

Density:1.39±0.1 g/cm3(Predicted)

Storage Condition: Store in cool and dry places ,keep away from strong light 

Diminazen(e) is an anti-infective medication for animals that is sold under a variety of brand names (see drugbox). It is effective against certain protozoa such as Babesia, Trypanosoma and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.
Chemically it is a di-amidine, and it is used in form of the aceturate (N-acetylglycinate).
The mechanism is not well understood; it probably inhibits DNA replication, but also has affinity to RNA.

Funcation
Diminazene diaceturate is a trypanocidal and babesiacidal drug. It is active against a large number of tsetse transmitted trypanosomes causing Nagana including T.brucei, T.vivax and T.congolense and can also be used for treatment of Surra caused by T.evansi. Diminazene diaceturate is furthermore effective against most important species of Babesia causing Red water fever including B.bigemina, B.bovis, B.motasi, and B.ovis. Although administration of diminazene diaceturate leads to a rapid clinical cure, it does generally not completely eliminate Babesia spp.; it therefore does not interact with normal development of immunity. Resistance has been recorded, but of the curative drugs diminazene diaceturate has had the least problems.
Antipyrine has analgesic and antipyretic actions. It minimizes the fever and listlessness related to infection with trypanosoma and /or babesia spp.. It furthermore acts as a stabilizer after preparing the solution.