Dihydrotanshinone I NEW
| Price | $51 | $92 | $191 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Dihydrotanshinone I | CAS No.: 87205-99-0 |
| Purity: 99.37% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Dihydrotanshinone I |
| Description | Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases. |
| Kinase Assay | Cells are treated with various concentrations of Dihydrotanshinone I (3.13-20 μM) for 48 h. For the activity assay, Ac-DEVD-AMC (1 μg/μL), Ac-IETD-AMC (1 μg/μL) or Ac-LEDH-AMC (1 μg/μL) and cell lysate are added into Protease Assay Buffer in 96-well plate. Reaction mixtures with lysis buffer are used as negative controls. Cells treated with DMSO (0.1%) are treated as vehicle control. The reaction mixtures are incubated for 1 h at 37°C. The AMC liberated from the substrates is measured using spectrofluorometer of Victor 2 plate reader with an excitation wavelength of 380 nm and an emission wavelength of 430 nm. |
| In vitro | Dihydrotestosterone (DHT, 10 nM) effectively reduces the expression of lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4), alongside diminishing reactive oxygen species (ROS) production, nuclear translocation of NF-κB, ox-LDL endocytosis, and monocyte adhesion in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs)[1]. Additionally, Dihydrotanshinone I prompts caspase-dependent apoptosis in HCT116 cells, with this apoptosis being both concentration and ROS dependent. The presence of Z-VAD-fmk entirely prevents apoptosis, while pre-treatment with Z-LEHD-fmk significantly reduces it, and Z-IETD-fmk only achieves partial inhibition. Intriguingly, knocking down caspase-2 significantly enhances apoptosis induced by Dihydrotanshinone I[3]. |
| In vivo | In ApoE-/- mice fed with an atherogenic diet, DHT (10 and 25 mg kg-1) significantly attenuated atherosclerotic plaque formation, altered serum lipid profile, decreased oxidative stress and shrunk necrotic core areas. DHT dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta[1]. Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.85 mg/mL (13.82 mM), Sonication is recommended. |
| Keywords | SARS coronavirus | inhibit | SARS-CoV | Dihydrotanshinone I | Inhibitor |
| Inhibitors Related | Nirmatrelvir | EIDD-1931 | Remdesivir | Silymarin | Umifenovir hydrochloride | Hydroxychloroquine | Chloroquine phosphate | Tempol | Inosine | Lycopene | Dexamethasone | Ethyl cinnamate |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-Viral Compound Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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