Desmethylglycitein NEW
| Price | $188 | $568 | $752 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Desmethylglycitein | CAS No.: 17817-31-1 |
| Purity: 97.93% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Desmethylglycitein |
| 描述 | Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. |
| 體外活性 | Molecular studies showed that Desmethylglycitein significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that Desmethylglycitein significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice. |
| 體內(nèi)活性 | A single administration of Desmethylglycitein significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.Moreover, treatment with Desmethylglycitein alone enhanced learning and memory performance in the same behavioral tests. Desmethylglycitein improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 125 mg/mL (462.55 mM), Sonication is recommended. |
| 關(guān)鍵字 | PI3K | Inhibitor | 4',6,7-Trihydroxyisoflavone | Phosphoinositide 3-kinase | Cyclin dependent kinase | PKC | Desmethylglycitein | inhibit | CDK | Protein kinase C |
| 相關(guān)產(chǎn)品 | Ribociclib | Myricetin | Erucic acid | α-Vitamin E | 3-Methyladenine | Isoprenaline hydrochloride | CASIN | Sodium Oxamate | Quercetin | Abemaciclib | Quercetin Dihydrate | Apilimod |
| 相關(guān)庫 | 抗癌天然產(chǎn)物庫 | 黃酮類天然產(chǎn)物庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 激酶抑制劑庫 | 植物來源化合物庫 | 天然產(chǎn)物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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