Desfesoterodine NEW
| Price | $60 | $147 | $228 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: Desfesoterodine | CAS No.: 207679-81-0 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | Desfesoterodine |
| 描述 | Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
| 體外活性 | Desfesoterodine is a major pharmacologically active metabolite of tolterodine. Desfesoterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. Desfesoterodine antagotizes muscarinic receptors with a pA2 of 9.1. Desfesoterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] Desfesoterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of Desfesoterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3] |
| 體內(nèi)活性 | Desfesoterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. Desfesoterodine is three times more potent at the urinary bladder compared to the salivary gland. [1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 63 mg/mL (184.5 mM) DMSO : 65 mg/mL (190.34 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Muscarinic acetylcholine receptor | metabolite | PNU-200583 | Fesoterodine | inhibit | receptor | PNU200577 | Tolterodine | muscarinic | pA2 | Desfesoterodine | Inhibitor | PNU 200577 | mAChR | 5-Hydroxymethyl Tolterodine |
| 相關(guān)產(chǎn)品 | Adiphenine hydrochloride | Ribavirin | Choline chloride | Propoxur |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 膜蛋白靶向化合物庫 | 神經(jīng)遞質(zhì)受體化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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