Product Details
| Product Name:
Demethylwedelolactone |
CAS No.:
6468-55-9 |
| Purity:
99.8% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Demethylwedelolactone |
| Description | Demethylwedelolactone is a natural product isolated from Eclipta alba, has trypsin inhibitory effect an IC50 of 3.0 μM. it exerts anti-invasive growth effect on breast cancer cells. |
| In vitro | demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 22.5 mg/mL (74.95 mM)
|
| Keywords | Inhibitor | Demethylwedelolactone | inhibit | Ser/Thr Protease | Serine proteases | Threonine proteases | Serine endopeptidases |
| Inhibitors Related | PMSF | Nafamostat mesylate | Diminazene Aceturate | AEBSF hydrochloride | 2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one | Leupeptin Hemisulfate | Ceritinib | Aprotinin | Sivelestat | 4-Aminobenzamidine dihydrochloride | 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)- | Benzamidine hydrochloride |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2018-12-24 |
United States