Deferasirox NEW
| Price | $43 | $61 | $79 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Deferasirox | CAS No.: 201530-41-8 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Deferasirox |
| 描述 | Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload. |
| 細(xì)胞實(shí)驗(yàn) | Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50 μM of deferasirox for 24 or 48 h, and proliferation is determined by an MTT assay[2]. |
| 體外活性 | Orally administered Deferasirox in rats achieves an absorption rate of at least 75% with a bioavailability of 26%. Monotherapy with Deferasirox modestly increases the survival time in IPA mice. When administered, either intravenously or orally, Deferasirox mainly circulates in the blood as its unaltered form and its iron complex, with a 99.2% binding rate to plasma proteins. Deferasirox significantly enhances survival rates and reduces tissue fungal burden in mice with diabetic ketoacidosis or neutropenia suffering from mucormycosis, showing effects comparable to those of liposomal Amphotericin B. Additionally, Deferasirox bolsters the host inflammatory response against mucormycosis. The combined use of Deferasirox and liposomal Amphotericin B synergistically improves survival rates and decreases fungal load in tissues affected by mucormycosis. |
| 體內(nèi)活性 | Deferasirox exhibits antifungal activity against Aspergillus with MIC (Minimum Inhibitory Concentration) and MFC (Minimum Fungicidal Concentration) values of 25 and 50 mg/L, respectively. It effectively chelates iron ions from Rhizopus species, showing antiviral activity in vitro against 28 out of 29 Mucorales clinical isolates at concentrations much lower than those achievable in clinical serum levels. Deferasirox significantly inhibits the activity of NF-κB by chelating its active subunit p65 in an inactive form within the cytoplasm in 28 out of 40 peripheral blood samples. Additionally, it inhibits three human myeloid cell lines (K562, U937, and HL60) with IC50 values ranging from 17 to 50 mM. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 50 mg/mL (133.92 mM) Ethanol : 2 mg/mL (5.35 mM) |
| 關(guān)鍵字 | Bacterial | chelator | transfusional | Inhibitor | CGP72670 | inhibit | available | ICL-670 | CGP 72670 | Ferroptosis | Deferasirox | overload | iron | orally | ICL670 |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Curcumin | L-Cystine | Dimethyl sulfoxide | Crystal Violet |
| 相關(guān)庫 | 表型篩選靶點(diǎn)鑒定庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抗菌活性庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 細(xì)胞周期化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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