Product Details
| Product Name:
dBRD9 |
CAS No.:
2170679-45-3 |
| Purity:
99.81% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | dBRD9 |
| 描述 | dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM. |
| 體外活性 | dBRD9 has prompt rapid BRD9 degradation over a broad range of concentrations. The degraded BRD9 showed significantly enhanced efficacy(10-to-100-fold). These findings reveal the tractability of non-BET bromodomain-containing proteins to chemical degradation and highlight lead compound dBRD9 as a tool for the study of BRD9[1]. |
| 體內(nèi)活性 | The final concentration of dBRD9 of 0.3 nM was mixed in silk fibroin hydrogel and injected into mice. It was found that BRD9 degradant alleviated ZOL-related ONJ. The ONJ-dBRD9 group is filled with well-organized newly formed trabecular bone, with 80% reduced incidence rate of osteonecrosis and periosteal reaction compared with the ONJ-control group[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 90.0 mg/mL (114.8 mM), Sonication is recommended.
|
| 關(guān)鍵字 | dBRD9 |
| 相關(guān)產(chǎn)品 | ARV-393 HCl | Gefitinib-based PROTAC 3 | ACBI1 | ARV-471 | dBET6 | dBET1 | ARV-825 | β-NF-JQ1 | C004019 | GMB-475 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | PPI抑制劑庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$197.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
|
|
$0.00/100MG |
VIP1Y
|
Hubei Chuchang Biotech Co., Ltd.
|
2024-04-17 |
United States