Daidzein NEW

Price	$5	$0.1
Package	1KG	1000KG

Min. Order:	1KG
Supply Ability:	g-kg-tons, free sample is available
Update Time:	2024-03-27

Product Details

Product Name: Daidzein	CAS No.: 486-66-8
Min. Order: 1KG	Purity: 98%
Supply Ability: g-kg-tons, free sample is available	Release date: 2024/03/27
COA, MSDS: Available, contact us for details	Name: Tina
Origin: Manufacturer, advantage product	Delivery: By express, by air, by sea
Packaging: bag/bottle/drum/IBC	Lead time: In stock, ready for shipment

1. Materials information

Name	daidzein
Synonym	More Synonyms

Description	Daidzein is a soy isoflavone, which acts as a PPAR activator.
Related Catalog	Research Areas >> Endocrinology Natural Products >> Flavonoids
Target	PPAR-α PPAR-γ
In Vitro	In 3T3-L1 adipocytes, Daidzein inverses the attenuation of adiponectin gene expression by co-culture, and these effects are inhibited by the PPAR-γ specific inhibitor. Daidzein attenuates the reduction of adiponectin expression in adipocytes, and a PPAR-γ specific inhibitor abrogated this effect. Direct activation of PPAR-α and-γ by Daidzein is confirmed by a luciferase reporter assay. In HEK293T cells, Daidzein significantly increases PPAR-α transcriptional activity in a concentration-dependent manner. Although an obvious dose-dependency is not observed in PPAR-γ transcriptional activity, Daidzein also significantly increases PPAR-γ transcriptional activity over a similar range of concentrations at which Daidzein enhanced PPAR-α transcriptional activity, with a maximum increase at 25 μM[1]. Daidzein is a soy isoflavone, which upregulates the expression of Abcg1, and it promotes axonal outgrowth in cultured hippocampal neurons via estrogen receptor signaling. Daidzein is a major component of soy with structural similarity to estrogen. It exerts an anti-inflammatory effect, lowers lipid levels, and increases mitochondrial biogenesis. As an activator of nuclear receptor peroxisome proliferator-activated receptors (PPARs), Daidzein enhances transcription of PPARs-dependent genes, including liver X receptors (LXRs, Nr1h gene family in mice). Incubation with different concentrations of Daidzein, from 5 to 100 μM, increases APOE transcriptional activity[2].
In Vivo	Treating Apoe KO mice with Daidzein increases Lxr and Abca1 gene expression at 1 month after stroke, showing that the absence of ApoE does not interfere with other cholesterol homeostasis genetic programs. Therefore, the findings suggest that Daidzein-induced ApoE upregulation is a critical component in fostering functional recovery in chronic stroke[2].
Cell Assay	HEK293T cells are plated on 24-well plates at a cell density of approximately 2.5×104 cells/well and are grown to 70-80% confluence. Cells are then transiently transfected with a PPAR-α or PPAR-γ expression plasmid, and a plasmid containing the luciferase gene under the control of three tandem PPAR response elements (PPRE × 3 TK-luciferase) using an X-treme GENE HP DNA Transfection Reagent. Renilla luciferase control vectors are co-transfected to control for transfection efficiency. After transfection, cells are cultured for another 24 h in medium containing DMSO or various concentrations (6.25, 12.5, 25 μM) of Daidzein. Cells are lysed, and luciferase activity is measured and expressed as fold induction, that is normalized to the activity of the renilla luciferase control plasmid[1].
Animal Admin	Mice[2] Experiments are performed in 10- to 11-week-old male C57 (C57 bl/6) and Apoe KO (C57 background) mice. For long-term stroke recovery, mice receive Moxifloxacin (100 mg/kg) for 3 d. The prophylactic antibiotic treatment is shown to effectively reduce mortality in an animal model of stroke by attenuating peripheral infection. In addition, saline is subcutaneously administered daily, and hydrogel (Clear H2O) is given to prevent dehydration. With the implementation of poststroke care (antibiotic regimen, rehydration, and feeding hydrogels with soft diet) during the acute period (<1 week), mice start to regain their body weight by day 5 and continue to recover from stroke. Animals are randomly selected for vehicle or Daidzein treatment. Vehicle or Daidzein (10 mg/kg) is administered subcutaneously within 30 min of reperfusion after confirming the reperfusion of blood flow, daily for 7 d and then every other day up to 1 month.
References	[1]. Sakamoto Y1, et al. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures. PLoS One. 2016 Feb 22;11(2):e0149676. [2]. Kim E, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015 Nov 11;35(45):15113-26.

Density	1.4±0.1 g/cm3
Boiling Point	512.8±50.0 °C at 760 mmHg
Melting Point	315-323°C (dec.)
Molecular Formula	C15H10O4
Molecular Weight	254.238
Flash Point	201.2±23.6 °C
Exact Mass	254.057907
PSA	70.67000
LogP	2.78
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.699
Storage condition	2-8°C
Water Solubility	insoluble

Daidzein MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3100040

CHEMICAL NAME :
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-

CAS REGISTRY NUMBER :
486-66-8

BEILSTEIN REFERENCE NO. :
0231523

LAST UPDATED :
199709

DATA ITEMS CITED :
1

MOLECULAR FORMULA :
C15-H10-O4

MOLECULAR WEIGHT :
254.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
>2 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/38
Safety Phrases	S24-S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3100040

7-benzyloxy-3-(...

1621-59-6

~94%

Daidzein

486-66-8

Literature: KaoHsiung Medical University Patent: US2010/298581 A1, 2010 ; Location in patent: Page/Page column 8 ;

Formononetin

485-72-3

~66%

Daidzein

486-66-8

Literature: Matin, Azadeh; Gavande, Navnath; Kim, Moon S.; Yang, Nancy X.; Salam, Noeris K.; Hanrahan, Jane R.; Roubin, Rebecca H.; Hibbs, David E. Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6835 - 6850

2-Bromo-4'-...

2491-38-5

b-Resorcylaldeh...

95-01-2

~80%

Daidzein

486-66-8

Literature: Mishra, Priya; Singh, Sarita; Ankit, Preyas; Fatma, Shahin; Singh, Divya; Singh, Jagdamba Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1070 - 1076

Precursor 9	Previous 1/3 Next
CAS#:485-72-3 Formononetin CAS#:2491-38-5 2-Bromo-4'-hydr... CAS#:95-01-2 b-Resorcylaldehyde CAS#:56401-06-0 7-Benzyldaidzein
DownStream 10	Previous 1/3 Next
CAS#:17817-31-1 6,7,4'-Trihydro... CAS#:40957-83-3 Glycitein CAS#:485-63-2 3',4',7-trihydr... CAS#:485-72-3 Formononetin

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

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3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

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By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

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By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

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4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

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