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Postion:Product Catalog >CZC-25146 hydrochloride
CZC-25146 hydrochloride
  • CZC-25146 hydrochloride

CZC-25146 hydrochloride NEW

Price $30 $67 $119
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-01

Product Details

Product Name: CZC-25146 hydrochloride CAS No.: 1330003-04-7
Purity: 99.06% Supply Ability: 10g
Release date: 2024/11/01

Product Introduction

Bioactivity

名稱CZC-25146 hydrochloride
描述CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
體外活性CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro.
體內(nèi)活性CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (104.76 mM)
關(guān)鍵字Leucine-rich repeat kinase 2 | CZC25146 | neurons | CZC-25146 Hydrochloride | LRRK2 G2019S | CZC 25146 | Inhibitor | liver diseases | inflammatory | Parkinson's disease | LRRK2 | inhibit | CZC-25146 | CZC 25146 Hydrochloride | CZC25146 Hydrochloride | CZC 25146 hydrochloride | CZC25146 hydrochloride
相關(guān)產(chǎn)品PFE-360 | GNE0877 | CZC-25146 | GSK2578215A | GNE-9605 | GNE-7915 | LRRK2 inhibitor 1 | LRRK2-IN-7 | LRRK2-IN-1 | CCG-1423
相關(guān)庫神經(jīng)退行性疾病化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 自噬庫 | 抗帕金森病化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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