Cysteamine hydrochloride NEW
| Price | $29 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Cysteamine hydrochloride | CAS No.: 156-57-0 |
| Purity: 99.34% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Cysteamine hydrochloride |
| Description | Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant. |
| In vitro | Cysteamine enhances intracellular glutathione (GSH) levels in cystinotic cells, effectively restoring their altered redox state and demonstrating antioxidant capabilities by increasing glutathione production, thus scavenging harmful OH and HOCl. It also mitigates increased apoptosis rates in cystinotic cells by counteracting the effects of elevated caspase 3 and protein kinase Cε activity. Furthermore, Cysteamine boosts the production of various heat shock proteins (HSP), notably murine Hsp40. It exhibits a dose-dependent mitigation of doxorubicin-induced death in cancer cells, including HeLa and B16 cells, without affecting cell survival on its own. Remarkably, it enhances the efficacy of doxorubicin in doxorubicin-resistant breast cancer cells, significantly increasing cell death. Additionally, Cysteamine (100 μM) not only heightens intracellular GSH levels but also improves the development of matured oocytes to the blastocyst stage in embryo cultures. [1][2] |
| In vivo | Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1] |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 22 mg/mL (193.6 mM) H2O : 21 mg/mL (184.8 mM) DMSO : 60 mg/mL (528.12 mM) |
| Keywords | cystinosis | b-Mercaptoethylamine Hydrochloride | antioxidant | 2-Aminoethanethiol | nephropathic | Autophagy | Apoptosis | Inhibitor | Reactive Oxygen Species | Cysteamine | Cysteamine hydrochloride | Endogenous Metabolite | inhibit | Cysteamine Hydrochloride | beta-Mercaptoethylamine Hydrochloride | orally | 2-Mercaptoethylamine |
| Related Compound Libraries | Drug Repurposing Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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