Cucurbitacin B NEW
| Price | $44 | $97 | $167 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Cucurbitacin B | CAS No.: 6199-67-3 |
| Purity: 99.33% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Cucurbitacin B |
| 描述 | Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells. |
| 細胞實驗 | For proliferation measurements, the cells are placed into 96 well plates, and cell growth is measured at various times by MTT assay according to the protocol.(Only for Reference) |
| 體外活性 | Cucurbitacin B inhibits the growth of 5 GBM cell lines: U87, U118, U343, U373 and T98 g by affecting the cytoskeleton and the JNK pathway, with ED50 ranged from 5 nM to 100 nM. Cucurbitacin B also causes cell cycle arrest at the G2/M phase, decreases cell migration and induces apoptosis of GBM cells. [1] In human breast cancer cell lines, Cucurbitacin B also inhibits cell growth with ED50 varied from 30.3 nM to 418 nM, and rapidly induces cytoskeletal disruption. [2] In addition, Cucurbitacin B possesses immunomodulatory and anti-inflammatory effects, depending on the induction of heme oxygenase-1 expression via Nrf2 activation. [3] |
| 體內(nèi)活性 | In nude mice bearing MDA-MB-231 tumors, Cucurbitacin B (1 mg/kg, i.p.) inhibits tumor growth by 55 %, and causes lower serum glucose levels. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 91 mg/mL (162.9 mM) Chloroform, Dichloromethane, Ethyl Acetate : Soluble Ethanol : 50 mg/mL (89.49 mM) |
| 關鍵字 | Inhibitor | Integrin | Apoptosis | inhibit | Endogenous Metabolite | Autophagy | Cucurbitacin B |
| 相關產(chǎn)品 | Sucrose | Dextran sulfate sodium salt (MW 4500-5500) | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Tributyrin | Ferulic Acid | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid | Oleic acid |
| 相關庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 植物來源化合物庫 | 天然產(chǎn)物庫 | 神經(jīng)保護化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 古代經(jīng)典名方目錄分子庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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